DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)m5-HLH and HEYL

DIOPT Version :9

Sequence 1:NP_524511.1 Gene:E(spl)m5-HLH / 43158 FlyBaseID:FBgn0002631 Length:178 Species:Drosophila melanogaster
Sequence 2:NP_055386.2 Gene:HEYL / 26508 HGNCID:4882 Length:328 Species:Homo sapiens


Alignment Length:177 Identity:43/177 - (24%)
Similarity:71/177 - (40%) Gaps:62/177 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEMLEAALVFMRKQVVKQQAPV 81
            |..:.::|::||.|:|..|..|:.||.   |.||..   :::|||:|:                 
Human    45 KKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSS---KLEKAEVLQ----------------- 89

  Fly    82 SPLPMDSFK-------NGYMNAVSEISRVMACTPAMSVD---VG-----KTVMTHLGVEFQRMLQ 131
              :.:|..|       .|:.:|           .|::||   :|     ..|:.:|||......:
Human    90 --MTVDHLKMLHATGGTGFFDA-----------RALAVDFRSIGFRECLTEVIRYLGVLEGPSSR 141

  Fly   132 ADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAASPKPVEETMWRPW 178
            ||.|:.       |.||..:| |.::.|.|.:...  |:....| ||
Human   142 ADPVRI-------RLLSHLNS-YAAEMEPSPTPTG--PLAFPAW-PW 177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)m5-HLHNP_524511.1 HLH 20..72 CDD:238036 17/54 (31%)
ORANGE 87..131 CDD:128787 12/58 (21%)
HEYLNP_055386.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 3/11 (27%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 21/98 (21%)
HLH 42..100 CDD:238036 19/76 (25%)
ORANGE 115..162 CDD:128787 14/54 (26%)
Atrophin-1 <136..311 CDD:331285 14/53 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..308
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140918
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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