DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and HEY2

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_036391.1	Gene:	HEY2 / 23493	HGNCID:	4881	Length:	337	Species:	Homo sapiens

Alignment Length:	164	Identity:	41/164 - (25%)
Similarity:	75/164 - (45%)	Gaps:	25/164 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NSTTFVSKTQHYLKVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEMLEAA-- 66
            ||.|..|:.. ..|.::.::|::||.|:|..|..|:.||.   |.||.   .:::|||:|:..
Human    38 NSPTTTSQIM-ARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS---AKLEKAEILQMTVD 98

  Fly    67 -LVFMRKQVVKQQAPVSPLPMDSFKNGYMNAVSEISRVMACTPAM--SVDVGKTVMTHLGVEFQR 128
             |..::....|.......|.||....|:...::|::|.::....:  |..:...:::||..
Human    99 HLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLST---- 159

  Fly   129 MLQADQVQTSVTTST----PRPLSP---ASSGYH 155
              .|.|.:.:..||:    ..||.|   |::.:|
Human   160 --CATQREAAAMTSSMAHHHHPLHPHHWAAAFHH 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	18/57 (32%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	7/45 (16%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		5/14 (36%)
		bHLH-O_HEY2	40..121	CDD:381490	23/84 (27%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		19/72 (26%)
		ORANGE	119..165	CDD:128787	10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..337
		YRPW motif	327..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740