DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and lin-22

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_500281.1	Gene:	lin-22 / 177082	WormBaseID:	WBGene00003008	Length:	173	Species:	Caenorhabditis elegans

Alignment Length:	145	Identity:	36/145 - (24%)
Similarity:	69/145 - (47%)	Gaps:	28/145 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KVK-KPLLERQRRARMNKCLDTLKTLVAEFQGDDAI--LRMDKAEMLEAALVFMRKQVVKQQAPV 81
            |:| |||:|::||||:||.|..||.::.:.:..::|  .:.:||::||.|:.::::....|...:
Worm    22 KIKNKPLMEKKRRARINKSLSQLKQILIQDEHKNSIQHSKWEKADILEMAVEYLQQLRSAQPCSL 86

  Fly    82 SPL----------------------PMDSFKNGYMN---AVSEISRVMACTPAMSVDVGKTVMTH 121
            ||.                      |:.||.|..|.   |..:::::...|...:...|..:...
Worm    87 SPSTSSISTPPTPKEEIRNIKVPLNPIASFLNPMMQQYVAYQQLAQLSMYTQLFNNPAGVPLRAD 151

  Fly   122 LGVEFQRMLQADQVQ 136
            .||..|....|::::
Worm   152 AGVTAQSPELAEKLK 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	21/54 (39%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	10/46 (22%)
lin-22	NP_500281.1	bHLH_O_HES	29..82	CDD:381416	16/52 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770