Protein Alignment E(spl)m5-HLH and ref-1

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_496204.1
• Gene: ref-1 / 174585
• WormBaseID: WBGene00004334
• Length: 367
• Species: Caenorhabditis elegans
• Alignment Length: 226
• Identity: 46/226 - (20%)
• Similarity: 81/226 - (35%)
• Gaps: 58/226 - (25%)

  Fly     4 QSNNSTTFVSKTQHYLKVKKPLLERQRRARMNKCLDTLKTLVAE--FQGDDAILRMDKAEMLEAA 66
            ||::.:|..|......|..|...|:.||.|..:..|.||..:.|  ......:.:|.:...|:..
 Worm   148 QSSSPSTSESGITIDRKEVKKNREQDRRDRQGEAFDALKNFIIENKLMTSHQVEKMQRLNTLDII 212

  Fly    67 LVFMRKQVVKQQAPVSPLPMDSFKNGYMNAVSEISR----------------VMACT-------- 107
            :.:::.   |:...||  ..|..::.|.:|::|..:                |:.|.
 Worm   213 IAYIQN---KKHNFVS--RSDQEQSLYAHAIAEGKKTAKNIAFQFFKSDRHLVVRCADLEKFFEF 272

  Fly   108 ----------PAMSVDV---GKTVMTHLGVEFQRMLQA-------DQVQTSVTTSTPRPLSPASS 152
                      |:|.:.:   ...:.......|..|..|       .|...|.:..:|.|.|..||
 Worm   273 SLSPKPLFGFPSMPIPIPPPSFPIFPFRPFPFFPMPMAPMATSPKSQQSPSYSLDSPPPSSDTSS 337

  Fly   153 GY----HSDNEDSQSAASPKPVEET-MWRPW 178
            ..    .:.||:|.|  :||...:: ::|||
 Worm   338 SSIETPSTPNENSNS--NPKASRKSKLFRPW 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	13/59 (22%)
		ORANGE	87..131	CDD:128787	10/80 (13%)
ref-1	NP_496204.1	HLH	20..66	CDD:197674
		HLH	170..217	CDD:197674	10/46 (22%)