Protein Alignment E(spl)m5-HLH and Hey2

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_038932.1
• Gene: Hey2 / 15214
• MGIID: 1341884
• Length: 339
• Species: Mus musculus
• Alignment Length: 169
• Identity: 42/169 - (24%)
• Similarity: 78/169 - (46%)
• Gaps: 30/169 - (17%)

  Fly     4 QSNNSTTFVSKTQHYL--KVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEML 63
            :||:.||    |...:  |.::.::|::||.|:|..|..|:.||.   |.||.   .:::|||:|
Mouse    36 RSNSPTT----TSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS---AKLEKAEIL 93

  Fly    64 EAA---LVFMRKQVVKQQAPVSPLPMDSFKNGYMNAVSEISRVMACTPAM--SVDVGKTVMTHLG 123
            :..   |..::....|.......|..|....|:...::|::|.::....:  |..:...:::||.
Mouse    94 QMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLS 158

  Fly   124 VEFQRMLQADQVQTSVTTST----PRPLSP---ASSGYH 155
            .      .|.|.:.:|.||:    ..||.|   |::.:|
Mouse   159 T------CASQREAAVMTSSMAHHHHPLHPHHWAAAFHH 191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	19/63 (30%)
		ORANGE	87..131	CDD:128787	7/45 (16%)
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		6/19 (32%)
		bHLH-O_HEY2	40..121	CDD:381490	23/87 (26%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269|PubMed:11486045	47..116		19/71 (27%)
		ORANGE	120..165	CDD:128787	9/50 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..339
		YQPW motif	329..332