DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and Hey1

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_034553.2	Gene:	Hey1 / 15213	MGIID:	1341800	Length:	299	Species:	Mus musculus

Alignment Length:	92	Identity:	25/92 - (27%)
Similarity:	46/92 - (50%)	Gaps:	9/92 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEMLEAA---LVFMRKQVVKQQ 78
            |.::.::|::||.|:|..|..|:.||.   |.||.   .:::|||:|:..   |..:.....|..
Mouse    51 KRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS---AKLEKAEILQMTVDHLKMLHTAGGKGY 112

  Fly    79 APVSPLPMDSFKNGYMNAVSEISRVMA 105
            .....|.||....|:...::|::|.::
Mouse   113 FDAHALAMDYRSLGFRECLAEVARYLS 139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	18/57 (32%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	4/19 (21%)
Hey1	NP_034553.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		1/1 (100%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	48..117		19/68 (28%)
		HLH	50..107	CDD:238036	18/58 (31%)
		ORANGE	120..166	CDD:128787	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..234
		YRPW motif	289..292
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740