Protein Alignment E(spl)m5-HLH and Hes5

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: XP_006538625.3
• Gene: Hes5 / 15208
• MGIID: 104876
• Length: 415
• Species: Mus musculus
• Alignment Length: 226
• Identity: 42/226 - (18%)
• Similarity: 78/226 - (34%)
• Gaps: 87/226 - (38%)

  Fly     1 MAPQSNNSTTFVSKTQHYLKVKKPLLERQRRARMNKCLDTLKTLV-AEFQGDDAILRMDKAEMLE 64
            ::|:..|            :::||::|:.||.|:|..::.||.|: .||.......:::||::||
Mouse   229 LSPKEKN------------RLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILE 281

  Fly    65 AALVFMRKQ----------------VVKQQAPVSPLPM--------------DSFKNGYMNAVSE 99
            .|:.:::..                ....:||:.||.:              ..:..||...:.|
Mouse   282 MAVSYLKHSKGEPGACARLLLPADVAPTARAPLMPLRLPTAFAAAAGPKSLHQDYSEGYSWCLQE 346

  Fly   100 ISRVMACTPAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSA 164
                                   .|:|..:..|...|..:.....||.:||:..    .|.....
Mouse   347 -----------------------AVQFLTLHAASDTQMKLLYHFQRPPAPAAPA----KEPPAPG 384

  Fly   165 ASPKPVEET-----------------MWRPW 178
            |:|:|...:                 :||||
Mouse   385 AAPQPARSSAKAAAAAVSTSRQPACGLWRPW 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	17/74 (23%)
		ORANGE	87..131	CDD:128787	5/43 (12%)
Hes5	XP_006538625.3	bHLH-O_HES5	236..292	CDD:381467	17/55 (31%)
		ORANGE	334..369	CDD:128787	7/57 (12%)