Protein Alignment E(spl)m5-HLH and Hes3

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: XP_011248491.1
• Gene: Hes3 / 15207
• MGIID: 104877
• Length: 291
• Species: Mus musculus
• Alignment Length: 219
• Identity: 54/219 - (24%)
• Similarity: 88/219 - (40%)
• Gaps: 54/219 - (24%)

  Fly     2 APQSNNSTTFV-----SKTQHYLK---VKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAILR-M 57
            ||..:..|..|     |:....||   :.|||:|::||||:|..|:.|::|:..........| :
Mouse    85 APSPHRGTASVAQPAASERSGVLKGMGISKPLMEKKRRARINVSLEQLRSLLERHYSHQIRKRKL 149

  Fly    58 DKAEMLEAALVFMRKQVVKQQAPVSPLPMD-SFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTH 121
            :||::||.::.:||......|. :.|:|.. .:.:|:...:..:|:.:......|
Mouse   150 EKADILELSVKYMRSLQNSLQG-LWPVPSGVDYPSGFQGGLRGVSQRLRPGEGDS---------- 203

  Fly   122 LGVEFQRMLQADQVQTS-----VTTSTPRPLSP-------ASSGYHSDN----------EDSQSA 164
             |:....:||..:..|:     ..||...|..|       |:.|.||..          |.|...
Mouse   204 -GLRCPLLLQRREGSTTDSANPQATSVLNPCLPAIWAPSRAAGGSHSPQSPLPLPGGLLESSTDV 267

  Fly   165 ASPKP-----VEET-----MWRPW 178
            .:|.|     .|.|     :||||
Mouse   268 VAPHPASNCQAESTRPGFRVWRPW 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	20/61 (33%)
		ORANGE	87..131	CDD:128787	4/44 (9%)
Hes3	XP_011248491.1	bHLH-O_HES3	117..171	CDD:381503	16/53 (30%)