Protein Alignment E(spl)m5-HLH and Hes1

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_032261.1
• Gene: Hes1 / 15205
• MGIID: 104853
• Length: 282
• Species: Mus musculus
• Alignment Length: 263
• Identity: 55/263 - (20%)
• Similarity: 98/263 - (37%)
• Gaps: 87/263 - (33%)

  Fly     3 PQSNNSTTFVSKT-QHYLKVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAI--LRMDKAEMLE 64
            |.|.|:|....|| ..:.|..||::|::||||:|:.|..||||:.:....|:.  .:::||::||
Mouse    18 PASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILE 82

  Fly    65 AALVFMRK-QVVKQQAPVS--PLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLG--- 123
            ..:..:|. |..:..|.:|  |..:..::.|:...::|::|.::....::.:|...::.||.
Mouse    83 MTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCM 147

  Fly   124 VEFQRMLQADQVQTSVTTSTPRPLS---------------------------------------- 148
            .:...|....|...::....|.|.|
Mouse   148 TQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAG 212

  Fly   149 ------------PASSG--------------------YHSDNEDS--QSAASPKP----VEETMW 175
                        ||..|                    |.|::..|  .:|.||..    ..::||
Mouse   213 EAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMW 277

  Fly   176 RPW 178
            |||
Mouse   278 RPW 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	21/60 (35%)
		ORANGE	87..131	CDD:128787	7/46 (15%)
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		9/25 (36%)
		bHLH-O_HES1_4	33..95	CDD:381465	21/61 (34%)
		Hairy_orange	109..148	CDD:462193	6/38 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..204		4/45 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..282		9/25 (36%)
		WRPW motif	277..280		2/2 (100%)