DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and hes2

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	XP_002933889.1	Gene:	hes2 / 100038090	XenbaseID:	XB-GENE-486138	Length:	191	Species:	Xenopus tropicalis

Alignment Length:	172	Identity:	51/172 - (29%)
Similarity:	84/172 - (48%)	Gaps:	23/172 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDD--AILRMDKAEMLEAALVFMRKQVVKQQAPVS 82
            |..|||:|::||||:|:.|:.||||:....|.|  ...:::||::||..:.|:|      ..|..
Frog    30 KTLKPLMEKRRRARINESLNQLKTLILPLIGKDNSRYSKLEKADILEMTVRFLR------DIPPV 88

  Fly    83 PL--PMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRM--LQADQVQTSVTTST 143
            |.  |.|.:|.||...|..:|.::..:..::.:....::.||    ||.  |..........:.:
Frog    89 PAQNPADRYKEGYRACVERLSAILNKSHVLTGEASNRLLNHL----QRSPELCCSDCHHPPKSHS 149

  Fly   144 PR---PLSPASSGYHSD--NEDSQSAASPKP--VEETMWRPW 178
            ||   .:||.:|...|.  |:.|....:|.|  :..::||||
Frog   150 PRIVLHVSPRTSQLESPLLNQPSSHRPAPCPPQLNSSIWRPW 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	22/53 (42%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	10/45 (22%)
hes2	XP_002933889.1	bHLH-O_HES2	25..89	CDD:381469	24/64 (38%)
hes2	XP_002933889.1	Hairy_orange	97..133	CDD:369405	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47782
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020