Protein Alignment E(spl)m3-HLH and BHLHE40

DIOPT Version :10

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_003661.1
• Gene: BHLHE40 / 8553
• HGNCID: 1046
• Length: 412
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 57/200 - (28%)
• Similarity: 96/200 - (48%)
• Gaps: 26/200 - (13%)

  Fly     4 EMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKL 68
            :..:||   |:...|:|:|||.|||:|:..||||:.|.|:.  ..:..||||.:||||:.|::.|
Human    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKL--TTLGHLEKAVVLELTLKHVKAL 107

  Fly    69 ------KQRGGLSLQ-GVVAGVGSPPTSTSTAHVES----FRSGYVHAADQITQVLLQTQQTDEI 122
                  :|:..::|| |:.||      ..|..:||:    |.||:...|.::.|.|.:.:.|.::
Human   108 TNLIDQQQQKIIALQSGLQAG------ELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDL 166

  Fly   123 GRKIMKFLSTRLIELQTQLLQ-QQQQQQQHQQQQIPQSSGRLAFPLLGGYGPAAAAAAISYSSFL 186
            .   ...|.|.|..:.::||| ...::......::.....:.:.|..|..||......:...:|.
Human   167 K---SSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFA 228

  Fly   187 TSKDE 191
            .|..|
Human   229 HSSGE 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	28/71 (39%)
		ORANGE	96..136	CDD:128787	11/43 (26%)
BHLHE40	NP_003661.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer	1..139		37/101 (37%)
		bHLH-O_DEC1	40..129	CDD:381592	34/91 (37%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	11/46 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..303		9/51 (18%)