DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and hes6.2

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001072210.1	Gene:	hes6.2 / 779656	XenbaseID:	XB-GENE-479404	Length:	189	Species:	Xenopus tropicalis

Alignment Length:	214	Identity:	62/214 - (28%)
Similarity:	96/214 - (44%)	Gaps:	43/214 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSL 76
            ||:.|||:|||||.|||.||:.||:.:::....:   .::||||||||:||.|::.:::.
Frog    18 RKLRKPLIERKRRERINTCLEQLKETVIKAFHLD---QSKLEKADILEMTVRHLQNIQKS----- 74

  Fly    77 QGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQTQL 141
                ...|.|...:..|. :.|.:||:....::..:||.....|..       |..||:
Frog    75 ----KSTGEPSQGSVDAQ-QRFSTGYIQCMHELHSLLLTCDWMDPA-------LGARLL------ 121

  Fly   142 LQQQQQQQQHQQQQIPQSSGRLAFPLLGGYGPAAAAAAISYSSFLTSKDELIDVTSVDGNALSET 206
                    .|..:.:|:..||.||.:....|......:.|.|      |...:.|||..:  |:.
Frog   122 --------NHLLKSLPRPEGRTAFLIQDYEGDTGRTMSPSLS------DCEAEQTSVPLH--SDV 170

  Fly   207 ASVSSQES-GASEPVWRPW 224
            |...:|.| ..|..:||||
Frog   171 AQGKTQCSLLRSLQMWRPW 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	28/57 (49%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	9/39 (23%)
hes6.2	NP_001072210.1	bHLH_O_HES	25..75	CDD:381416	23/61 (38%)
hes6.2	NP_001072210.1	Hairy_orange	91..129	CDD:369405	10/58 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I4979
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1483774at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.060