DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and Hes3

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_073178.1	Gene:	Hes3 / 64628	RGDID:	621339	Length:	175	Species:	Rattus norvegicus

Alignment Length:	219	Identity:	62/219 - (28%)
Similarity:	88/219 - (40%)	Gaps:	57/219 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LERKRRARINKCLDDLKDLMVECLQQEGEHVTR---LEKADILELTVDHMRKLKQRGGLSLQG-- 78
            :|:|||||||..|:.|:.|    |::...|..|   |||||||||:|.::|.|:.    ||||
  Rat     1 MEKKRRARINLSLEQLRSL----LERHYSHQIRKRKLEKADILELSVKYVRSLQN----SLQGLW 57

  Fly    79 -VVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQTQLL 142
             |.:||..|         ..||.|...::.::      ....|:.|             |:..||
  Rat    58 LVPSGVDYP---------SGFRGGLPGSSQRL------RPGEDDSG-------------LRCPLL 94

  Fly   143 QQQQQQQQHQQQQIPQSSGRLA--FPLLGGYGPAAAAAAISYSSFLTSKDELIDVTSVDGNALSE 205
            .|::......... ||::..|:  .|.:...||.|..:....|.|......|...|.:
  Rat    95 LQRRAGSTTDSAN-PQTASVLSPCLPAIWAPGPPAGGSQSPQSPFPPLGGLLESSTGI------- 151

  Fly   206 TASVSSQESGASEP-----VWRPW 224
            .|...:....|..|     |||||
  Rat   152 LAPPPASNCQAENPRPGFRVWRPW 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	26/53 (49%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	5/39 (13%)
Hes3	NP_073178.1	bHLH-O_HES3	1..55	CDD:381503	28/61 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..175		13/57 (23%)
		WRPW motif	172..175		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840