DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and bhlhe41

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001027504.1	Gene:	bhlhe41 / 613096	XenbaseID:	XB-GENE-994875	Length:	427	Species:	Xenopus tropicalis

Alignment Length:	173	Identity:	51/173 - (29%)
Similarity:	85/173 - (49%)	Gaps:	20/173 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKL 68
            |..:||   |:...|:|:|||.|||:|:..||||:.|.|:.  ..:..||||.:||||:.|::.|
Frog    39 ESKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKL--TTLGHLEKAVVLELTLKHLKGL 98

  Fly    69 ------KQRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIM 127
                  :.:..::||.....:.||    ....:::|.||:...|.::.|.|.:.:......::..
Frog    99 TSLTEQQHQKIMALQNGEHALKSP----IQTDLDAFHSGFQTCAKEVLQYLSRFESWTSRDQRCT 159

  Fly   128 KFLSTRLIELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGG 170
            :.|: .|..:.:|:|...|.    ..|.:|...|..|.|..||
Frog   160 QLLN-HLHTVSSQILSSSQL----LLQSVPGGKGSSASPGRGG 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	26/64 (41%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	8/39 (21%)
bhlhe41	NP_001027504.1	bHLH-O_DEC2	30..121	CDD:381593	31/86 (36%)
bhlhe41	NP_001027504.1	ORANGE	128..168	CDD:128787	8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100