DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and Heyl

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_038933.2	Gene:	Heyl / 56198	MGIID:	1860511	Length:	326	Species:	Mus musculus

Alignment Length:	230	Identity:	55/230 - (23%)
Similarity:	96/230 - (41%)	Gaps:	62/230 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            |.||..:.::|::||.|||..|.:|:.|:....:::|.  ::||||::|::||||::.|...||.
Mouse    42 QARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHASGGT 104

  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRS-GYVHAADQITQVL--LQ--TQQTDEIGRKIMKFLSTRL 134
            ..            ..:.|....||| |:.....::.:.|  |:  :...|.:..:::..|.:..
Mouse   105 GF------------FDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYA 157

  Fly   135 IELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGGYGPAAAAAAISYSSFLTS-------KDEL 192
            .|::..                |.::..||||:...             |||.|       ..:|
Mouse   158 AEMEPS----------------PTTTSALAFPVWPW-------------SFLHSCPGLPSLNSQL 193

  Fly   193 IDVTSVDGNALSETAS----VSSQESGASEPVWRP 223
            ..:..|.|..|...:|    :|:..|.   ||.||
Mouse   194 AILGRVPGPVLPSISSPPYPISALRSA---PVHRP 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	22/58 (38%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	8/44 (18%)
Heyl	NP_038933.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		4/13 (31%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		25/82 (30%)
		HLH	44..100	CDD:238036	22/57 (39%)
		ORANGE	115..162	CDD:128787	9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..260		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740