Protein Alignment E(spl)m3-HLH and HES2

DIOPT Version :9

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 64/224 - (28%)
• Similarity: 97/224 - (43%)
• Gaps: 71/224 - (31%)

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            :.||.:|||||::||||||:.|..||.|::..|.:|..:.::|||||:||:||..:::|
Human    12 ELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQEL------ 70

  Fly    75 SLQGVVAGVGSPPTSTSTA---HVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIE 136
                       |.:|..||   ..:|:|.||.....::.:||       ...|.:...:|.||:|
Human    71 -----------PASSWPTAAPLPCDSYREGYSACVARLARVL-------PACRVLEPAVSARLLE 117

  Fly   137 LQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGG-----YGPAAAAAAISYSSFLTSKDELIDVT 196
                          |..::...::      |.||     .||:|.|.|.:      |..|
Human   118 --------------HLWRRAASAT------LDGGRAGDSSGPSAPAPAPA------SAPE----- 151

  Fly   197 SVDGNALSETASVSSQESGASEP-VWRPW 224
                   ..:|.|.|..|....| :||||
Human   152 -------PASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	29/58 (50%)
		ORANGE	96..136	CDD:128787	10/39 (26%)
HES2	NP_061962.2	HLH	12..70	CDD:238036	28/57 (49%)
		ORANGE	84..127	CDD:128787	12/63 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		17/62 (27%)
		WRPW motif	170..173		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840