Protein Alignment E(spl)m3-HLH and helt

DIOPT Version :10

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_996948.1
• Gene: helt / 404275
• ZFINID: ZDB-GENE-040824-6
• Length: 270
• Species: Danio rerio
• Alignment Length: 227
• Identity: 55/227 - (24%)
• Similarity: 90/227 - (39%)
• Gaps: 63/227 - (27%)

  Fly     3 MEMSKTYQYRK--VMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHM 65
            |..||....:|  |...::|::||.|||:||::|...:...|.::..  .:||||:|||:||.::
Zfish    49 MMASKMKDRKKTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQNS--GKLEKAEILEMTVQYL 111

  Fly    66 RKL--------KQRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVL-----LQTQ 117
            |.|        :::|.|                .|.....|..||......:...|     ::|:
Zfish   112 RALHSADFPRGREKGEL----------------LTEFANYFHYGYHECMKNLVHYLTTVERMETK 160

  Fly   118 QTDEIGRKIMKFLSTRLI----------------ELQTQLLQQQQQQQQHQQQQIP------QSS 160
            .|..  .:|:.||.::::                :|..||..|.....:...||.|      .||
Zfish   161 DTKY--ARILAFLQSKVVTEPVFGSLGTISPDPTDLLCQLEYQSPSPTESVFQQSPPGHFSWHSS 223

  Fly   161 GR---LAFPLL---GGYGPAAAAAAISYSSFL 186
            .|   ||:|.:   .||..........|.:|:
Zfish   224 TRSPTLAYPAMSQHSGYLSPVQGLDHHYMNFI 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	25/75 (33%)
		ORANGE	96..136	CDD:128787	9/60 (15%)
helt	NP_996948.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		bHLH-O_HELT	63..118	CDD:381414	21/56 (38%)
		Hairy_orange	135..173	CDD:462193	9/39 (23%)