DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(spl)m3-HLH and helt

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_996948.1	Gene:	helt / 404275	ZFINID:	ZDB-GENE-040824-6	Length:	270	Species:	Danio rerio

Alignment Length:	227	Identity:	55/227 - (24%)
Similarity:	90/227 - (39%)	Gaps:	63/227 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MEMSKTYQYRK--VMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHM 65
            |..||....:|  |...::|::||.|||:||::|...:...|.::..  .:||||:|||:||.::
Zfish    49 MMASKMKDRKKTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQNS--GKLEKAEILEMTVQYL 111

  Fly    66 RKL--------KQRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVL-----LQTQ 117
            |.|        :::|.|                .|.....|..||......:...|     ::|:
Zfish   112 RALHSADFPRGREKGEL----------------LTEFANYFHYGYHECMKNLVHYLTTVERMETK 160

  Fly   118 QTDEIGRKIMKFLSTRLI----------------ELQTQLLQQQQQQQQHQQQQIP------QSS 160
            .|..  .:|:.||.::::                :|..||..|.....:...||.|      .||
Zfish   161 DTKY--ARILAFLQSKVVTEPVFGSLGTISPDPTDLLCQLEYQSPSPTESVFQQSPPGHFSWHSS 223

  Fly   161 GR---LAFPLL---GGYGPAAAAAAISYSSFL 186
            .|   ||:|.:   .||..........|.:|:
Zfish   224 TRSPTLAYPAMSQHSGYLSPVQGLDHHYMNFI 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	23/68 (34%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	9/60 (15%)
helt	NP_996948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		HLH	62..115	CDD:278439	21/54 (39%)
		Hairy_orange	136..173	CDD:284859	9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740