DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and heyl

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_859425.1	Gene:	heyl / 335134	ZFINID:	ZDB-GENE-030131-7074	Length:	310	Species:	Danio rerio

Alignment Length:	255	Identity:	65/255 - (25%)
Similarity:	108/255 - (42%)	Gaps:	60/255 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSL 76
            ||..:.::|::||.|||..|.:|:.|:....:::|.  ::||||:||::||||::.|...||
Zfish    44 RKKRRGIIEKRRRDRINHSLSELRRLVPSAFEKQGS--SKLEKAEILQMTVDHLKLLHAMGG--- 103

  Fly    77 QGVVAGVGSPPTSTSTAHVESFRS-GYVHAADQITQVLLQ---TQQTDEIGRKIMKFLSTRLIEL 137
            :|..         .:.|....:|: |:.....::.:.|..   .:.:|.||.:::..||....||
Zfish   104 KGYF---------DARALAVDYRTLGFRECVGEVVRYLSSLEGVESSDPIGARLVSHLSHCASEL 159

  Fly   138 QTQLLQQQ----------QQQQQHQQQQIPQSSGRLAFP--------------LLGGYGPAAAAA 178
            . .|||..          ....|.|....|.||  ..||              :||...||....
Zfish   160 D-PLLQSPAALPFPPWPWASFPQLQAASPPASS--TPFPPNARRDLTPHGTATILGYPSPALRMG 221

  Fly   179 AIS-----YSSFLTSKDELIDVT---------SVDGNALSETASVSSQESGASEPVWRPW 224
            ::|     .:..|||..:|..|.         |.:|..:..::| ||..|...:..:||:
Zfish   222 SLSTQGTILNPALTSVRQLPSVPGHLHRLQQHSPEGRTVPSSSS-SSSNSSPPQISFRPF 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	23/57 (40%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	8/43 (19%)
heyl	NP_859425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		HLH	44..101	CDD:238036	23/58 (40%)
		ORANGE	115..159	CDD:128787	8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..208		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..310		8/34 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740