Protein Alignment E(spl)m3-HLH and HES1

DIOPT Version :9

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 70/266 - (26%)
• Similarity: 110/266 - (41%)
• Gaps: 71/266 - (26%)

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            ::||..||::|::||||||:.|..||.|:::.|:::....::||||||||:||.|:|.| ||..:
Human    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNL-QRAQM 96

  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQT 139
                      :...||..:.:..:|:|:....:::|:.|   ...:.:..::...|...|....|
Human    97 ----------TAALSTDPSVLGKYRAGFSECMNEVTRFL---STCEGVNTEVRTRLLGHLANCMT 148

  Fly   140 QLLQQQQQQQQHQQQQ-----------------------IPQSSGRLAFPLLGG----YGPAAAA 177
            |:.......|.|...|                       :|...|  |.|..||    .|..|..
Human   149 QINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGG--AAPPPGGAPCKLGSQAGE 211

  Fly   178 AAISYSSF------------------LTSKDELIDV------TSVDGNALSETASVSSQESGASE 218
            ||..:..|                  ......:|.|      |||..||:|.    ||..|..::
Human   212 AAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSP----SSGPSLTAD 272

  Fly   219 PVWRPW 224
            .:||||
Human   273 SMWRPW 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	29/58 (50%)
		ORANGE	96..136	CDD:128787	6/39 (15%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	31/62 (50%)
		Hairy_orange	110..148	CDD:400076	6/40 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		13/29 (45%)
		WRPW motif	275..278		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840