DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and Heyl

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001101447.1	Gene:	Heyl / 313575	RGDID:	1305022	Length:	326	Species:	Rattus norvegicus

Alignment Length:	163	Identity:	43/163 - (26%)
Similarity:	80/163 - (49%)	Gaps:	35/163 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            |.||..:.::|::||.|||..|.:|:.|:....:::|.  ::||||::|::||||::.|...||
  Rat    42 QARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHASGG- 103

  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRS-GYVHAADQITQVL--LQ--TQQTDEIGRKIMKFLSTRL 134
                  ||.     ..:.|....||| |:.....::.:.|  |:  :...|.:..:::..|::..
  Rat   104 ------AGF-----FDARALAVDFRSIGFRECLTEVVRYLGVLEGPSSHADPVRIRLLSHLNSYA 157

  Fly   135 IELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPL 167
            .|::..                |.::|.||||:
  Rat   158 AEMEPS----------------PTTTGALAFPV 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	22/58 (38%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	8/44 (18%)
Heyl	NP_001101447.1	bHLH-O_HEYL	36..109	CDD:381453	27/80 (34%)
Heyl	NP_001101447.1	ORANGE	115..162	CDD:128787	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740