Protein Alignment E(spl)m3-HLH and Hes1

DIOPT Version :10

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_077336.3
• Gene: Hes1 / 29577
• RGDID: 62081
• Length: 281
• Species: Rattus norvegicus
• Alignment Length: 261
• Identity: 68/261 - (26%)
• Similarity: 110/261 - (42%)
• Gaps: 60/261 - (22%)

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            ::||..||::|::||||||:.|..||.|:::.|:::....::||||||||:||.|:|.| ||..:
  Rat    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNL-QRAQM 96

  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQT 139
                      :...||..:.:..:|:|:....:::|:.|   ...:.:..::...|...|....|
  Rat    97 ----------TAALSTDPSVLGKYRAGFSECMNEVTRFL---STCEGVNTEVRTRLLGHLANCMT 148

  Fly   140 QLLQQQQQQQQHQQQQI---PQSSG-----RLAF-------PLLGGYGPAAAAA----------- 178
            |:.......|.|...|.   |..||     ...|       |:.||..|...:|
  Rat   149 QINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEA 213

  Fly   179 -------------------AISYSSFLTSKDELIDVTSVDGNALSETA-SVSSQESGASEPVWRP 223
                               .|...:|..|...:...||..|.::...| |.||..|..::.:|||
  Rat   214 AKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRP 278

  Fly   224 W 224
            |
  Rat   279 W 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	29/60 (48%)
		ORANGE	96..136	CDD:128787	6/39 (15%)
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	31/62 (50%)
		Hairy_orange	109..148	CDD:462193	6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..206		12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..281		9/25 (36%)
		WRPW motif	276..279		2/2 (100%)