Protein Alignment E(spl)m3-HLH and HEY2

DIOPT Version :9

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_036391.1
• Gene: HEY2 / 23493
• HGNCID: 4881
• Length: 337
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 58/298 - (19%)
• Similarity: 102/298 - (34%)
• Gaps: 101/298 - (33%)

  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSL 76
            ||..:.::|::||.|||..|.:|:.|:....:::|.  .:||||:||::||||::.|:..||
Human    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGG--- 108

  Fly    77 QGVVAGVGSPPTSTSTAH---VESFRSGYVHAADQITQVLLQTQ---QTDEIGRKIMKFLSTRLI 135
            :|..           .||   ::....|:.....::.:.|...:   .:|.:..:::..|||...
Human   109 KGYF-----------DAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCAT 162

  Fly   136 ELQTQLLQQQQQQQQH-----------------------------------QQQQIPQSSG---- 161
            :.:...:........|                                   ...::|.:.|
Human   163 QREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALL 227

  Fly   162 ---------RLAFPLLGGYGP------------------AAAAAAISYSSFLTSKDELIDVTSVD 199
                     .|..|..|...|                  |||||..:..||..|......:...:
Human   228 TATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPN 292

  Fly   200 GNA-------------LSETASVSSQESGASEPVWRPW 224
            ..|             :|.|:|.....||.:...:|||
Human   293 AAAAVAAATAISPPLSVSATSSPQQTSSGTNNKPYRPW 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	23/57 (40%)
		ORANGE	96..136	CDD:128787	6/42 (14%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		2/2 (100%)
		bHLH-O_HEY2	40..121	CDD:381490	28/87 (32%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		27/82 (33%)
		ORANGE	119..165	CDD:128787	6/45 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..337		8/24 (33%)
		YRPW motif	327..330		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740