DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and Bhlhe40

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_035628.1	Gene:	Bhlhe40 / 20893	MGIID:	1097714	Length:	411	Species:	Mus musculus

Alignment Length:	267	Identity:	68/267 - (25%)
Similarity:	101/267 - (37%)	Gaps:	80/267 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKL 68
            :..:||   |:...|:|:|||.|||:|:..||||:.|.|:.  ..:..||||.:||||:.|::.|
Mouse    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKL--TTLGHLEKAVVLELTLKHVKAL 107

  Fly    69 K-----------------QRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQT 116
            .                 |.|.||.:.:.||            .|.|.||:...|.::.|.|.:.
Mouse   108 TNLIDQQQQKIIALQSGLQAGDLSGRNLEAG------------QEMFCSGFQTCAREVLQYLAKH 160

  Fly   117 QQTDEIGRKIMKFLSTRLIELQTQLLQQQQQQQQHQQQQIPQSSG--------RLAFPLLGGYGP 173
            :.|.::.   ...|.|.|..:.::|||....::       |..|.        :.:|...|..||
Mouse   161 ENTRDLK---SSQLVTHLHRVVSELLQGGASRK-------PLDSAPKAVDLKEKPSFLAKGSEGP 215

  Fly   174 AAAAAAISYSSFLTSKDEL----IDVTSVDGN----------------------ALSETASVSSQ 212
            ......:...:|..|..|.    .|..|..|.                      |:.|..|...|
Mouse   216 GKNCVPVIQRTFAPSGGEQSGSDTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFAVGERVSTIKQ 280

  Fly   213 ESGASEP 219
            ||  .||
Mouse   281 ES--EEP 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	26/75 (35%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	11/39 (28%)
Bhlhe40	NP_035628.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		34/107 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	29/85 (34%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..294		18/81 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840