DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and Hey2

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_038932.1	Gene:	Hey2 / 15214	MGIID:	1341884	Length:	339	Species:	Mus musculus

Alignment Length:	300	Identity:	59/300 - (19%)
Similarity:	103/300 - (34%)	Gaps:	103/300 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSL 76
            ||..:.::|::||.|||..|.:|:.|:....:::|.  .:||||:||::||||::.|:..||
Mouse    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGG--- 108

  Fly    77 QGVVAGVGSPPTSTSTAH--VESFRS-GYVHAADQITQVLLQTQ---QTDEIGRKIMKFLSTRLI 135
            :|..           .||  ...|.| |:.....::.:.|...:   .:|.:..:::..|||...
Mouse   109 KGYF-----------DAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCAS 162

  Fly   136 ELQTQLLQQQQQQQQH-----------------------------------QQQQIPQSSG---- 161
            :.:..::........|                                   ...::|.:.|
Mouse   163 QREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHGSALL 227

  Fly   162 ---------RLAFPLLGGYGP------------------AAAAAAISYSSF---------LTSKD 190
                     .|..|..|...|                  |||||..:..||         :...:
Mouse   228 TATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSN 292

  Fly   191 ELIDVTSVDGNALSETASVSSQES------GASEPVWRPW 224
            ...........|:|...|||:..|      |.:...::||
Mouse   293 AAAAAAVAAATAISPPLSVSAASSPQQTSTGTNNKPYQPW 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	23/57 (40%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	8/43 (19%)
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/2 (100%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269\|PubMed:11486045	47..116		27/82 (33%)
		HLH	49..105	CDD:238036	23/57 (40%)
		ORANGE	120..165	CDD:128787	8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..339		6/22 (27%)
		YQPW motif	329..332		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740