Protein Alignment E(spl)m3-HLH and Hes3

DIOPT Version :10

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: XP_011248491.1
• Gene: Hes3 / 15207
• MGIID: 104877
• Length: 291
• Species: Mus musculus
• Alignment Length: 224
• Identity: 66/224 - (29%)
• Similarity: 98/224 - (43%)
• Gaps: 57/224 - (25%)

  Fly    14 VMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTR---LEKADILELTVDHMRKLKQRGGLS 75
            :.|||:|:|||||||..|:.|:.|    |::...|..|   |||||||||:|.:||.|:.    |
Mouse   112 ISKPLMEKKRRARINVSLEQLRSL----LERHYSHQIRKRKLEKADILELSVKYMRSLQN----S 168

  Fly    76 LQG---VVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRL--- 134
            |||   |.:||..|         ..|:.|                         ::.:|.||
Mouse   169 LQGLWPVPSGVDYP---------SGFQGG-------------------------LRGVSQRLRPG 199

  Fly   135 ---IELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGGYGPA-AAAAAISYSSFLTSKDELIDV 195
               ..|:..||.|:::........ ||::..|...|...:.|: ||..:.|..|.|.....|::
Mouse   200 EGDSGLRCPLLLQRREGSTTDSAN-PQATSVLNPCLPAIWAPSRAAGGSHSPQSPLPLPGGLLE- 262

  Fly   196 TSVDGNALSETASVSSQESGASEPVWRPW 224
            :|.|..|....::..::.:.....|||||
Mouse   263 SSTDVVAPHPASNCQAESTRPGFRVWRPW 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	30/59 (51%)
		ORANGE	96..136	CDD:128787	5/45 (11%)
Hes3	XP_011248491.1	bHLH-O_HES3	117..171	CDD:381503	29/61 (48%)