Protein Alignment E(spl)m3-HLH and Hes2

DIOPT Version :9

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_001288734.1
• Gene: Hes2 / 15206
• MGIID: 1098624
• Length: 157
• Species: Mus musculus
• Alignment Length: 219
• Identity: 58/219 - (26%)
• Similarity: 85/219 - (38%)
• Gaps: 77/219 - (35%)

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            :.||.:|||||::||||||:.|..||.|::..|..|....::||||||||:||..:::
Mouse    12 ELRKNLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILEMTVRFLQE------- 69

  Fly    75 SLQGVVAGVGSPPTSTSTA---HVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIE 136
                      .|.|..|:|   .:.|:..||.....::.:||......:..       :|.||:|
Mouse    70 ----------QPATLYSSAAPGPLNSYLEGYRACLARLARVLPACSVLEPA-------VSARLLE 117

  Fly   137 LQTQLLQQQQQQQQH-QQQQIPQSSGRLAFPLLGGYGPAAAAAAISYSSFLTSKDELIDVTSVDG 200
                          | :|:.:...|..|..|      ||.|.|
Mouse   118 --------------HLRQRTVSDDSPSLTLP------PAPAPA---------------------- 140

  Fly   201 NALSETASVSSQESGASEPVWRPW 224
                  .|......|:| .:||||
Mouse   141 ------PSPPVPPPGSS-GLWRPW 157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	29/58 (50%)
		ORANGE	96..136	CDD:128787	8/39 (21%)
Hes2	NP_001288734.1	bHLH_SF	10..73	CDD:381792	30/77 (39%)
		ORANGE	85..123	CDD:128787	11/58 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..157		12/67 (18%)
		WRPW motif	154..157		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I5264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.890