DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m3-HLH and hes2

DIOPT Version :9

Sequence 1:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	XP_002933889.1	Gene:	hes2 / 100038090	XenbaseID:	XB-GENE-486138	Length:	191	Species:	Xenopus tropicalis

Alignment Length:	223	Identity:	52/223 - (23%)
Similarity:	92/223 - (41%)	Gaps:	66/223 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74
            :.||.:|||:|::||||||:.|:.||.|::..:.::....::||||||||:||..:|.:
Frog    27 ELRKTLKPLMEKRRRARINESLNQLKTLILPLIGKDNSRYSKLEKADILEMTVRFLRDI------ 85

  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQ-QTDEIGRKIMKFLSTRLIELQ 138
                       ||...... .:.::.||....::::.:|.::. .|.|...:::..|. |..||.
Frog    86 -----------PPVPAQNP-ADRYKEGYRACVERLSAILNKSHVLTGEASNRLLNHLQ-RSPELC 137

  Fly   139 TQLLQQQQQQQQHQQQQI----PQSSGRLAFPLL---GGYGPAAAAAAISYSSFLTSKDELIDVT 196
            ..  ......:.|..:.:    |::| :|..|||   ..:.||.....::.|
Frog   138 CS--DCHHPPKSHSPRIVLHVSPRTS-QLESPLLNQPSSHRPAPCPPQLNSS------------- 186

  Fly   197 SVDGNALSETASVSSQESGASEPVWRPW 224
                                   :||||
Frog   187 -----------------------IWRPW 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	27/58 (47%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	7/40 (18%)
hes2	XP_002933889.1	bHLH-O_HES2	25..89	CDD:381469	29/78 (37%)
hes2	XP_002933889.1	Hairy_orange	97..133	CDD:369405	6/36 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010