Protein Alignment E(spl)mbeta-HLH and BHLHE40

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_003661.1
• Gene: BHLHE40 / 8553
• HGNCID: 1046
• Length: 412
• Species: Homo sapiens
• Alignment Length: 193
• Identity: 59/193 - (30%)
• Similarity: 92/193 - (47%)
• Gaps: 33/193 - (17%)

  Fly     6 EMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVE--CLTQEGEHITRLEKADILELTVEHMK 68
            :..:||   |:...::|:|||.|||:|:.:|||::.|  .||..|    .||||.:||||::|:|
Human    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG----HLEKAVVLELTLKHVK 105

  Fly    69 KLR---AQKQLRLSSVTGGVSPSADPKLSI---AESFRAGYVHAANEVSKTLAAVPGVSVDLGTQ 127
            .|.   .|:|.::.::..|:........::   .|.|.:|:...|.||.:.||..........:|
Human   106 ALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQ 170

  Fly   128 LMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGP 190
            |::|| ||      ||..|..|...:.|.:      |.|...|..|..:     |.|..:.||
Human   171 LVTHL-HR------VVSELLQGGTSRKPSD------PAPKVMDFKEKPS-----SPAKGSEGP 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	30/72 (42%)
		ORANGE	97..141	CDD:128787	14/43 (33%)
BHLHE40	NP_003661.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer	1..139		32/97 (33%)
		bHLH-O_DEC1	40..129	CDD:381592	32/87 (37%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	17/50 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..303		11/45 (24%)