DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and Bhlhe40

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_445780.2	Gene:	Bhlhe40 / 79431	RGDID:	68439	Length:	411	Species:	Rattus norvegicus

Alignment Length:	202	Identity:	60/202 - (29%)
Similarity:	94/202 - (46%)	Gaps:	36/202 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVE--CLTQEGEHITRLEKADILELTVEHMK 68
            :..:||   |:...::|:|||.|||:|:.:|||::.|  .||..|    .||||.:||||::|:|
  Rat    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG----HLEKAVVLELTLKHVK 105

  Fly    69 KLR---AQKQLRLSSVTGGVSPSADPKLSI---AESFRAGYVHAANEVSKTLAAVPGVSVDLGTQ 127
            .|.   .|:|.::.::..|:........:|   .|.|.:|:...|.||.:.||..........:|
  Rat   106 ALTNLIDQQQQKIMALQSGLQAGDLSGRNIEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQ 170

  Fly   128 LMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDS----LESGA------CSPAPS 182
            |::|| ||      ||..|..|...:.|::.    .|.|.:...    |..|:      |.|...
  Rat   171 LVTHL-HR------VVSELLQGSASRKPLDS----APKPVDFKEKPSFLAKGSEGPGKNCVPVIQ 224

  Fly   183 EASSTSG 189
            ...:.||
  Rat   225 RTFAPSG 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	28/66 (42%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	14/43 (33%)
Bhlhe40	NP_445780.2	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		33/97 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		bHLH-O_DEC1	40..129	CDD:381592	32/87 (37%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	17/50 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..293		9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840