DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and Bhlhe41

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_077789.1	Gene:	Bhlhe41 / 79362	MGIID:	1930704	Length:	410	Species:	Mus musculus

Alignment Length:	193	Identity:	56/193 - (29%)
Similarity:	90/193 - (46%)	Gaps:	49/193 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TYQYRKVMKPMLERKRRARINKCLDELKDIMVE--CLTQEGEHITRLEKADILELTVEHMKKLRA 72
            ||   |:...::|:|||.|||:|:.:|||::.|  .||..|    .||||.:||||::|:|.|.|
Mouse    44 TY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG----HLEKAVVLELTLKHLKALTA 101

  Fly    73 ---QKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAV-------PGVSVDLGTQ 127
               |:..::.::..|......|..:..::|.:|:...|.||.:.||..       |..:     |
Mouse   102 LTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCA-----Q 161

  Fly   128 LMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGP 190
            |:||| |.: ..|::.|.:|.|                       .....:|..:.|::.|||
Mouse   162 LVSHL-HAV-ATQLLTPQVPSG-----------------------RGSGRAPCSAGAAAASGP 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	29/66 (44%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	14/50 (28%)
Bhlhe41	NP_077789.1	bHLH-O_DEC2	31..122	CDD:381593	32/84 (38%)
		ORANGE	129..175	CDD:128787	15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..255
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840