DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and hey2

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_571697.2	Gene:	hey2 / 58146	ZFINID:	ZDB-GENE-000526-1	Length:	324	Species:	Danio rerio

Alignment Length:	189	Identity:	56/189 - (29%)
Similarity:	89/189 - (47%)	Gaps:	32/189 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRL 78
            ||..:.::|::||.|||..|.||:.::.....::|.  .:||||:||::||:|:|.|:|
Zfish    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLKMLQA------ 105

  Fly    79 SSVTGGVSPSADPKLSIAESFRA-GYVHAANEVSKTLAAVPGV--SVDLGTQLMSHLGHRLNYLQ 140
               |||  .......|:|..|.: |:.....||::.|::|.|:  |..|..:|:|||....:..:
Zfish   106 ---TGG--KGYFDAHSLAMDFLSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSSCASQRE 165

  Fly   141 VVVPSLPIGVPLQA--PVEDQAMVTP-----------PPSECDSLESGACSPAPSEASS 186
            ....:..|....||  |....|.:.|           |.||.   .||..|.||...::
Zfish   166 AAAMTTSIAHHQQALHPHHWAAALHPIPAAFLQQSGLPSSES---SSGRLSEAPQRGAA 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	24/60 (40%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	13/46 (28%)
hey2	NP_571697.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		HLH	49..105	CDD:238036	23/57 (40%)
		Hairy_orange	125..162	CDD:284859	12/36 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..324
		YRPW motif	314..317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740