DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and Heyl

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_038933.2	Gene:	Heyl / 56198	MGIID:	1860511	Length:	326	Species:	Mus musculus

Alignment Length:	185	Identity:	49/185 - (26%)
Similarity:	82/185 - (44%)	Gaps:	50/185 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQL 76
            |.||..:.::|::||.|||..|.||:.::.....::|.  ::||||::|::||:|:|.|.|
Mouse    42 QARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHA---- 100

  Fly    77 RLSSVTGGVSPSADPKLSIAESFRA-GYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQ 140
              |..||.....|     :|..||: |:.....||.:.|..:.|.|        ||..
Mouse   101 --SGGTGFFDARA-----LAVDFRSIGFRECLTEVIRYLGVLEGPS--------SHAD------- 143

  Fly   141 VVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPMWRPW 195
                  |:.:.|.:.::..|              ....|:|:..|:.:.|:| ||
Mouse   144 ------PVRIRLLSHLKSYA--------------AEMEPSPTTTSALAFPVW-PW 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	23/61 (38%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	10/44 (23%)
Heyl	NP_038933.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		4/13 (31%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		27/76 (36%)
		HLH	44..100	CDD:238036	22/57 (39%)
		ORANGE	115..162	CDD:128787	13/81 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..260
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740