Protein Alignment E(spl)mbeta-HLH and HES6

DIOPT Version :9

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_061115.2
• Gene: HES6 / 55502
• HGNCID: 18254
• Length: 224
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 57/242 - (23%)
• Similarity: 92/242 - (38%)
• Gaps: 103/242 - (42%)

  Fly    14 RKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMK-----KLRAQ 73
            ||..||::|:|||||||:.|.||:.::.....|     .:||.|::|||||..::     :.|.:
Human    26 RKARKPLVEKKRRARINESLQELRLLLAGAEVQ-----AKLENAEVLELTVRRVQGVLRGRARER 85

  Fly    74 KQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNY 138
            :||:..:               :|.|.|||:...:||...::....:...:..:|::||
Human    86 EQLQAEA---------------SERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHL------ 129

  Fly   139 LQVVVPSLPI--------------------------------GVPLQAPVEDQAMVTPPPSE--C 169
                :.|:|:                                |.|:.:|        |.|.:  |
Human   130 ----LESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSP--------PGPGDDLC 182

  Fly   170 DSLE---SGACSPAPSEASSTSGP------------------MWRPW 195
            ..||   ....|.||:|     ||                  :||||
Human   183 SDLEEAPEAELSQAPAE-----GPDLVPAALGSLTTAQIARSVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	25/65 (38%)
		ORANGE	97..141	CDD:128787	10/43 (23%)
HES6	NP_061115.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		2/4 (50%)
		HLH	23..75	CDD:238036	24/53 (45%)
		Hairy_orange	96..134	CDD:311465	10/47 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..205		14/70 (20%)
		WRPW motif	221..224		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1483774at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.710