Protein Alignment E(spl)mbeta-HLH and HES2

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 193
• Identity: 58/193 - (30%)
• Similarity: 90/193 - (46%)
• Gaps: 40/193 - (20%)

  Fly    12 QYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQL 76
            :.||.:||:||::||||||:.|.:||.:::..|.:|..:.::|||||:||:||..:::|.|...
Human    12 ELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSW- 75

  Fly    77 RLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQV 141
                      |:|.|  ...:|:|.||......:::.|.|...:...:..:|:.||..|.....:
Human    76 ----------PTAAP--LPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATL 128

  Fly   142 --------VVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGP-MWRPW 195
                    ..||.|...|..||                  ..|.:|.||..|...|| :||||
Human   129 DGGRAGDSSGPSAPAPAPASAP------------------EPASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	28/62 (45%)
		ORANGE	97..141	CDD:128787	10/43 (23%)
HES2	NP_061962.2	bHLH-O_HES2	10..74	CDD:381469	28/61 (46%)
		ORANGE	84..127	CDD:128787	10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		15/62 (24%)
		WRPW motif	170..173		2/2 (100%)