Protein Alignment E(spl)mbeta-HLH and hes1

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_001011194.1
• Gene: hes1 / 496617
• XenbaseID: XB-GENE-487995
• Length: 267
• Species: Xenopus tropicalis
• Alignment Length: 246
• Identity: 70/246 - (28%)
• Similarity: 112/246 - (45%)
• Gaps: 73/246 - (29%)

  Fly    12 QYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKL-RAQKQ 75
            ::||..||::|::||||||:.|.:||.::::.|.::....::||||||||:||:|::.| |.|..
 Frog    33 EHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMT 97

  Fly    76 LRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQ 140
            ..||:         ||  |:...:|||:....|||::.|:...||:.|:.|:|:.||.:.:|.:.
 Frog    98 AALST---------DP--SVLGKYRAGFSECMNEVTRFLSTCEGVNTDVRTRLLGHLANCMNQIN 151

  Fly   141 VV----VPSLP--------IGVPL-----QAPVEDQAMVT----PPPSECDSLESG--------- 175
            .:    .|.:|        .|.||     .||....|.:.    .||.|...:..|
 Frog   152 AMNYPTQPQIPAAAAPHPAYGQPLVQLQGAAPQSSPAPIACKMGGPPVEAAKVYGGFQLVPAPDG 216

  Fly   176 ----------------------------ACSPAPSEA---SSTSGPMWRPW 195
                                        |..|:.|.:   |.|:..:||||
 Frog   217 QFAFLITNPAFPHNGSVIPVYTNSNVGTALPPSVSPSVMPSVTADSVWRPW 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	29/63 (46%)
		ORANGE	97..141	CDD:128787	15/43 (35%)
hes1	NP_001011194.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		5/11 (45%)
		bHLH-O_HES1_4	33..95	CDD:381465	28/61 (46%)
		Hairy_orange	109..148	CDD:462193	14/38 (37%)
		WRPW motif. /evidence=ECO:0000255	264..267		2/2 (100%)