DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and cwo

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	182	Identity:	41/182 - (22%)
Similarity:	76/182 - (41%)	Gaps:	49/182 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRA 72
            :||.:...:...::|::||.|:|.||.:|..::.....::|.  .|:||.:|:|:.:.|:|.|::
  Fly    57 NKTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGR--GRIEKTEIIEMAIRHLKHLQS 119

  Fly    73 QKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLN 137
            :.|.:.|                  .:|:||:....|.:|.|..|.          |....|||
  Fly   120 ECQQKES------------------DYRSGYMDCMKEAAKFLYDVH----------MQDFCHRL- 155

  Fly   138 YLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSG 189
                      :| .||..:::.       .:.|..:|......|...|::||
  Fly   156 ----------LG-RLQEHIDEM-------FKTDCYKSTRSCHMPDNVSASSG 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	17/61 (28%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	11/43 (26%)
cwo	NP_524775.1	HLH	66..118	CDD:306515	16/53 (30%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	15/88 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438364
Domainoid	1	1.000	45	1.000	Domainoid score	I4621
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840