DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and E(spl)m7-HLH

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	99/214 - (46%)
Similarity:	126/214 - (58%)	Gaps:	47/214 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLEMEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVE 65
            |..:.||||||||||||||:||||||||||||||||||:|.||:.|.|:  .:.|||||||:||:
  Fly     1 MATKYEMSKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQ 63

  Fly    66 HMKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMS 130
            |::||:..|:          ...|:|:    :||||||:.||||||:.||::|.|.|..||.||:
  Fly    64 HLRKLKESKK----------HVPANPE----QSFRAGYIRAANEVSRALASLPRVDVAFGTTLMT 114

  Fly   131 HLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTS------- 188
            |||.|||.|:         .|::.|   ||:.||....|.|..|.:...:.|..||.|
  Fly   115 HLGMRLNQLE---------QPMEQP---QAVNTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYA 167

  Fly   189 ------------GPMWRPW 195
                        |.:||||
  Fly   168 SDNESLLQISSPGQVWRPW 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	42/61 (69%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	28/43 (65%)
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	42/61 (69%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	28/52 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469354
Domainoid	1	1.000	45	1.000	Domainoid score	I4621
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5073
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1483774at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1011
	9	8.900