DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and E(spl)mgamma-HLH

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster

Alignment Length:	217	Identity:	111/217 - (51%)
Similarity:	140/217 - (64%)	Gaps:	39/217 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEM-EMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEH 66
            |:| |||||||||||||||||||||||||||||||||:||..|..||||:|||||||||||||.|
  Fly     4 LQMSEMSKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTH 68

  Fly    67 MKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSH 131
            ::|::.|:|.:.:        |.|..|:.||.||:||:||.||||::|:.:||::|.||||||:|
  Fly    69 LQKMKQQRQHKRA--------SGDESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTH 125

  Fly   132 LGHRLNYLQVVVPS----LPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPM- 191
            ||.|||.:|   |:    ||:..||...:.::...:.|.|   .:.|.|.|| .|..||||..:
  Fly   126 LGQRLNQIQ---PAEKEVLPVTAPLSVHIANRDAYSVPIS---PISSYAGSP-NSNTSSTSHSLL 183

  Fly   192 ------------------WRPW 195
                              ||||
  Fly   184 TTIDVTKMEDDSEDEENVWRPW 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	49/61 (80%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	27/43 (63%)
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	49/61 (80%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	28/46 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469352
Domainoid	1	1.000	45	1.000	Domainoid score	I4621
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	1	1.000	-	-		H43735
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5073
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1483774at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	1	1.000	-	-		otm49703
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1011
	11	10.900