Protein Alignment E(spl)mbeta-HLH and HELT

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: XP_016863675.2
• Gene: HELT / 391723
• HGNCID: 33783
• Length: 298
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 52/233 - (22%)
• Similarity: 83/233 - (35%)
• Gaps: 84/233 - (36%)

  Fly     3 LEMEMSKTYQYRK----------VMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKA 57
            |.:|.|:...:.|          |...::|::||.|||:||:||...:...|.::..  .:||||
Human    46 LSVEESRVQSHPKHTTLSSQRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSS--GKLEKA 108

  Fly    58 DILELTVEHMKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSV 122
            :|||:||::::.|.:..           .|....|..:...| |.|.|....
Human   109 EILEMTVQYLRALHSAD-----------FPRGREKAELLAEF-ANYFHYGYH------------- 148

  Fly   123 DLGTQLMSHLGHRL-----------NYLQVVV-----------PSLPIGVPLQAPVEDQAMVTPP 165
                :.|.:|.|.|           .|.:::.           |:.|   ||.:        .|.
Human   149 ----ECMKNLVHYLTTVERMETKDTKYARILAFLQSKARLGAEPAFP---PLGS--------LPE 198

  Fly   166 PSECDSLESGA---CSPAPSEAS-----STSGPMWRPW 195
            |.....|....   ...:|.||:     |.:||.  ||
Human   199 PDFSYQLHPAGPEFAGHSPGEAAVFPQGSGAGPF--PW 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	24/77 (31%)
		ORANGE	97..141	CDD:128787	9/54 (17%)
HELT	XP_016863675.2	bHLH-O_HELT	70..125	CDD:381414	21/56 (38%)
		Hairy_orange	142..183	CDD:462193	7/57 (12%)