Protein Alignment E(spl)mbeta-HLH and HES3

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_001019769.1
• Gene: HES3 / 390992
• HGNCID: 26226
• Length: 186
• Species: Homo sapiens
• Alignment Length: 203
• Identity: 58/203 - (28%)
• Similarity: 82/203 - (40%)
• Gaps: 53/203 - (26%)

  Fly    21 LERKRRARINKCLDELKDIMVECLTQEGEHITR---LEKADILELTVEHMKKLRAQKQLRLSSVT 82
            :|:|||||||..|::||.:    |.:...|..|   |||||||||:|::|:.|:...|.......
Human     1 MEKKRRARINVSLEQLKSL----LEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPR 61

  Fly    83 GGVSPSADPKL--SIAESFRAGYVHAANEVSKTLAA--VP----GVSVDLGTQLMSHLGHRLNYL 139
            |...||.....  .:::..|.|     :||...|..  ||    |.::|     .:.||.....|
Human    62 GAEQPSGFRSCLPGVSQLLRRG-----DEVGSGLRCPLVPESAAGSTMD-----SAGLGQEAPAL 116

  Fly   140 ------QVVVPSLPIGVPLQAP--------VEDQAMVTPPPSECDSLESGACSPAPSEASSTSG- 189
                  .|..|:...|.|...|        :...:...|||           .||.|..:.:.|
Human   117 FRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPP-----------QPASSRCAESPGL 170

  Fly   190 --PMWRPW 195
              .:||||
Human   171 GLRVWRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	26/56 (46%)
		ORANGE	97..141	CDD:128787	12/55 (22%)
HES3	NP_001019769.1	bHLH-O_HES3	1..55	CDD:381503	26/57 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..186		14/62 (23%)
		WRPW motif	175..178		2/2 (100%)