DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)mbeta-HLH and HES3

DIOPT Version :9

Sequence 1:NP_524505.2 Gene:E(spl)mbeta-HLH / 43152 FlyBaseID:FBgn0002733 Length:195 Species:Drosophila melanogaster
Sequence 2:NP_001019769.1 Gene:HES3 / 390992 HGNCID:26226 Length:186 Species:Homo sapiens


Alignment Length:203 Identity:58/203 - (28%)
Similarity:82/203 - (40%) Gaps:53/203 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LERKRRARINKCLDELKDIMVECLTQEGEHITR---LEKADILELTVEHMKKLRAQKQLRLSSVT 82
            :|:|||||||..|::||.:    |.:...|..|   |||||||||:|::|:.|:...|.......
Human     1 MEKKRRARINVSLEQLKSL----LEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPR 61

  Fly    83 GGVSPSADPKL--SIAESFRAGYVHAANEVSKTLAA--VP----GVSVDLGTQLMSHLGHRLNYL 139
            |...||.....  .:::..|.|     :||...|..  ||    |.::|     .:.||.....|
Human    62 GAEQPSGFRSCLPGVSQLLRRG-----DEVGSGLRCPLVPESAAGSTMD-----SAGLGQEAPAL 116

  Fly   140 ------QVVVPSLPIGVPLQAP--------VEDQAMVTPPPSECDSLESGACSPAPSEASSTSG- 189
                  .|..|:...|.|...|        :...:...|||           .||.|..:.:.| 
Human   117 FRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPP-----------QPASSRCAESPGL 170

  Fly   190 --PMWRPW 195
              .:||||
Human   171 GLRVWRPW 178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)mbeta-HLHNP_524505.2 HLH 13..75 CDD:238036 26/56 (46%)
ORANGE 97..141 CDD:128787 12/55 (22%)
HES3NP_001019769.1 HLH 1..54 CDD:238036 26/56 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..186 14/62 (23%)
WRPW motif 175..178 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140884
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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