Protein Alignment E(spl)mbeta-HLH and HES5

DIOPT Version :9

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: XP_005244808.1
• Gene: HES5 / 388585
• HGNCID: 19764
• Length: 198
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 57/213 - (26%)
• Similarity: 92/213 - (43%)
• Gaps: 44/213 - (20%)

  Fly     5 MEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTV---EH 66
            :|:....:..::.||::|:.||.|||..:::|| :::|......:..::||||||||:.|   :|
Human     8 VELLSPKEKNRLRKPVVEKMRRDRINSSIEQLK-LLLEQEFARHQPNSKLEKADILEMAVSYLKH 71

  Fly    67 MKKLRAQKQLRLSSVTGGVSP-----------------SADPKLSIAESFRAGYVHAANEVSK-- 112
            .|..||:.....||......|                 :|.|| |:.:.:..||.....|..:
Human    72 SKGERARAPRAPSSHRAPAPPRPAARSPPPRLPAAFVAAAGPK-SLHQDYSEGYSWCLQEAVQFL 135

  Fly   113 TLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGAC 177
            ||.|    :.|...:|:.|...        .|:.| ..|.:.|....|  .|||    :|.:.|.
Human   136 TLHA----ASDTQMKLLYHFQR--------PPAAP-AAPAKEPKAPGA--APPP----ALSAKAT 181

  Fly   178 SPAPSEASSTSGPMWRPW 195
            :.|.:......| :||||
Human   182 AAAAAAHQPACG-LWRPW 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	24/64 (38%)
		ORANGE	97..141	CDD:128787	9/45 (20%)
HES5	XP_005244808.1	HLH	14..71	CDD:238036	20/57 (35%)
		Hairy_orange	118..153	CDD:295407	9/38 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1011
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840