DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and her2

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	XP_005155978.1	Gene:	her2 / 30300	ZFINID:	ZDB-GENE-980526-274	Length:	133	Species:	Danio rerio

Alignment Length:	181	Identity:	46/181 - (25%)
Similarity:	74/181 - (40%)	Gaps:	64/181 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLS 79
            |:.||::|:.||.|||||:::|| |:::...:..:..::||||||||:.|.::|. .|....|..
Zfish    17 KLRKPVVEKMRRDRINKCIEQLK-ILLKTEIKASQPCSKLEKADILEMAVIYLKN-TADAHARSY 79

  Fly    80 SVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVP 144
            |.            :.|:|:..||.....|.::.|:|                 |:    |....
Zfish    80 SE------------AHAQSYADGYSRCIEETARFLSA-----------------HK----QTQKH 111

  Fly   145 SLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPMWRPW 195
            |.|:         |...:|                  ||.:...  :||||
Zfish   112 SKPV---------DSCQIT------------------SEIAKHG--LWRPW 133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	25/59 (42%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	7/43 (16%)
her2	XP_005155978.1	HLH	13..70	CDD:238036	23/53 (43%)
her2	XP_005155978.1	ORANGE	85..133	CDD:128787	16/97 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840