DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mbeta-HLH and HEYL

DIOPT Version :9

Sequence 1:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_055386.2	Gene:	HEYL / 26508	HGNCID:	4882	Length:	328	Species:	Homo sapiens

Alignment Length:	158	Identity:	51/158 - (32%)
Similarity:	81/158 - (51%)	Gaps:	22/158 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEMEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHM 67
            |....|...|.||..:.::|::||.|||..|.||:.::.....::|.  ::||||::|::||:|:
Human    33 LSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHL 95

  Fly    68 KKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRA-GYVHAANEVSKTLAAVPGVSV---DLGTQL 128
            |.|.|         |||.. ..|.: ::|..||: |:.....||.:.|..:.|.|.   .:..:|
Human    96 KMLHA---------TGGTG-FFDAR-ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRL 149

  Fly   129 MSHLGHRLNYLQVVVPS-LPIGVPLQAP 155
            :|||.   :|...:.|| .|.| ||..|
Human   150 LSHLN---SYAAEMEPSPTPTG-PLAFP 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	23/61 (38%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	13/47 (28%)
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		7/23 (30%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		28/81 (35%)
		HLH	42..100	CDD:238036	23/59 (39%)
		ORANGE	115..162	CDD:128787	13/49 (27%)
		Atrophin-1	<136..311	CDD:331285	14/42 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740