Protein Alignment E(spl)mbeta-HLH and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_035628.1
• Gene: Bhlhe40 / 20893
• MGIID: 1097714
• Length: 411
• Species: Mus musculus
• Alignment Length: 198
• Identity: 58/198 - (29%)
• Similarity: 92/198 - (46%)
• Gaps: 28/198 - (14%)

  Fly     6 EMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVE--CLTQEGEHITRLEKADILELTVEHMK 68
            :..:||   |:...::|:|||.|||:|:.:|||::.|  .||..|    .||||.:||||::|:|
Mouse    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG----HLEKAVVLELTLKHVK 105

  Fly    69 KLR---AQKQLRLSSVTGGVSPS--ADPKLSIA-ESFRAGYVHAANEVSKTLAAVPGVSVDLGTQ 127
            .|.   .|:|.::.::..|:...  :...|... |.|.:|:...|.||.:.||..........:|
Mouse   106 ALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQ 170

  Fly   128 LMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGA------CSPAPSEASS 186
            |::|| ||      ||..|..|...:.|::..........:...|..|:      |.|......:
Mouse   171 LVTHL-HR------VVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFA 228

  Fly   187 TSG 189
            .||
Mouse   229 PSG 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	30/72 (42%)
		ORANGE	97..141	CDD:128787	14/43 (33%)
Bhlhe40	NP_035628.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		33/97 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	32/87 (37%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	17/50 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..294		2/5 (40%)