Protein Alignment E(spl)mbeta-HLH and Hey1

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_034553.2
• Gene: Hey1 / 15213
• MGIID: 1341800
• Length: 299
• Species: Mus musculus
• Alignment Length: 257
• Identity: 60/257 - (23%)
• Similarity: 96/257 - (37%)
• Gaps: 89/257 - (34%)

  Fly    14 RKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRL 78
            ||..:.::|::||.|||..|.||:.::.....::|.  .:||||:||::||:|:|.|.
Mouse    50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKMLH------- 105

  Fly    79 SSVTGGVSPSADPKLSIAESFRA-GYVHAANEVSKTLAAVPGV--SVDLGTQLMSHLG------- 133
               |.|.....|.. ::|..:|: |:.....||::.|:.:.|:  |..|..:|:|||.
Mouse   106 ---TAGGKGYFDAH-ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQRE 166

  Fly   134 -----------------------------------------------HRLNYLQVVVPSLPI--- 148
                                                           |....|....|..|.
Mouse   167 AASGAHGGLGHIPWGSAFGHHPHIAHPLLLPQNGHGNAGTAASPTEPHHQGRLASAHPEAPALRA 231

  Fly   149 ----GVPLQAPVEDQAMVTPPP--SECDSLES--------GACSPA-PSEASSTSGPMWRPW 195
                |:....||...|....||  |...||.:        ...||: |::|::...| :|||
Mouse   232 PPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFSSFHLLSPSTPTQAANLGKP-YRPW 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	23/60 (38%)
		ORANGE	97..141	CDD:128787	14/100 (14%)
Hey1	NP_034553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		2/2 (100%)
		bHLH_SF	41..122	CDD:469605	27/84 (32%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	48..117		26/79 (33%)
		ORANGE	120..166	CDD:128787	12/45 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..234		4/39 (10%)
		YRPW motif	289..292		1/2 (50%)