Protein Alignment E(spl)mbeta-HLH and Hes5

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: XP_006538625.3
• Gene: Hes5 / 15208
• MGIID: 104876
• Length: 415
• Species: Mus musculus
• Alignment Length: 217
• Identity: 51/217 - (23%)
• Similarity: 90/217 - (41%)
• Gaps: 53/217 - (24%)

  Fly     5 MEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKK 69
            :||....:..::.||::|:.||.|||..:::|| :::|......:..::||||||||:.|.::|.
Mouse   226 VEMLSPKEKNRLRKPVVEKMRRDRINSSIEQLK-LLLEQEFARHQPNSKLEKADILEMAVSYLKH 289

  Fly    70 LRAQ---------------------KQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSK- 112
            .:.:                     ..|||.:   ..:.:|.|| |:.:.:..||.....|..:
Mouse   290 SKGEPGACARLLLPADVAPTARAPLMPLRLPT---AFAAAAGPK-SLHQDYSEGYSWCLQEAVQF 350

  Fly   113 -TLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGA 176
             ||.|    :.|...:|:.|      :.:...|:.|...|            |.|.........:
Mouse   351 LTLHA----ASDTQMKLLYH------FQRPPAPAAPAKEP------------PAPGAAPQPARSS 393

  Fly   177 CSPAPSEASSTSGP---MWRPW 195
            ...|.:..|::..|   :||||
Mouse   394 AKAAAAAVSTSRQPACGLWRPW 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	22/88 (25%)
		ORANGE	97..141	CDD:128787	9/45 (20%)
Hes5	XP_006538625.3	bHLH-O_HES5	236..292	CDD:381467	21/56 (38%)
		ORANGE	334..369	CDD:128787	9/44 (20%)