Protein Alignment E(spl)mbeta-HLH and Hes1

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_032261.1
• Gene: Hes1 / 15205
• MGIID: 104853
• Length: 282
• Species: Mus musculus
• Alignment Length: 266
• Identity: 72/266 - (27%)
• Similarity: 110/266 - (41%)
• Gaps: 100/266 - (37%)

  Fly    12 QYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKL-RAQKQ 75
            ::||..||::|::||||||:.|.:||.::::.|.::....::||||||||:||:|::.| |||..
Mouse    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97

  Fly    76 LRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQ 140
            ..||:         ||  |:...:|||:....|||::.|:...||:.::.|:|:.||.:.:..:.
Mouse    98 AALST---------DP--SVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQIN 151

  Fly   141 VVV----------------PSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSP---------- 179
            .:.                ||.|.| |..||      ..|||.....:..||..|
Mouse   152 AMTYPGQAHPALQAPPPPPPSGPAG-PQHAP------FAPPPPPLVPIPGGAAPPPGSAPCKLGS 209

  Fly   180 ------------------------------------------------------APSEASS-TSG 189
                                                                  :||..|| ||.
Mouse   210 QAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSD 274

  Fly   190 PMWRPW 195
            .|||||
Mouse   275 SMWRPW 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	30/63 (48%)
		ORANGE	97..141	CDD:128787	13/43 (30%)
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	28/61 (46%)
		Hairy_orange	109..148	CDD:462193	13/38 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..204		13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..282		11/25 (44%)
		WRPW motif	277..280		2/2 (100%)