Protein Alignment E(spl)mgamma-HLH and BHLHE40

DIOPT Version :10

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_003661.1
• Gene: BHLHE40 / 8553
• HGNCID: 1046
• Length: 412
• Species: Homo sapiens
• Alignment Length: 201
• Identity: 59/201 - (29%)
• Similarity: 86/201 - (42%)
• Gaps: 55/201 - (27%)

  Fly     4 LQMSEMSK-TYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVT-----RLEKADIL 62
            ::.||.|| ||   |:...::|:|||.|||:|:.:||||:       .||:.     .||||.:|
Human    43 IKRSEDSKETY---KLPHRLIEKKRRDRINECIAQLKDLL-------PEHLKLTTLGHLEKAVVL 97

  Fly    63 ELTVTH---LQKMKQQRQHK-----------RASGDESLTPAEGFRSGYIHAVNEVSRSLSQLPG 113
            |||:.|   |..:..|:|.|           ..||....|..|.|.||:.....||.:.|::...
Human    98 ELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162

  Fly   114 MNVSLGTQLMTHLGQRLNQI----------QPAEKEVLPVTAPLSVHIANRDAYSVPISPISSYA 168
            ......:||:|||.:.::::          .||.|.:              |....|.||.....
Human   163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVM--------------DFKEKPSSPAKGSE 213

  Fly   169 GSPNSN 174
            | |..|
Human   214 G-PGKN 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	bHLH-O_ESMB_like	9..77	CDD:381584	30/76 (39%)
		ORANGE	91..135	CDD:128787	12/53 (23%)
BHLHE40	NP_003661.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer	1..139		37/105 (35%)
		bHLH-O_DEC1	40..129	CDD:381592	34/95 (36%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..303		10/52 (19%)