DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)mgamma-HLH and BHLHE41

DIOPT Version :9

Sequence 1:NP_524504.2 Gene:E(spl)mgamma-HLH / 43151 FlyBaseID:FBgn0002735 Length:205 Species:Drosophila melanogaster
Sequence 2:NP_110389.1 Gene:BHLHE41 / 79365 HGNCID:16617 Length:482 Species:Homo sapiens


Alignment Length:196 Identity:52/196 - (26%)
Similarity:90/196 - (45%) Gaps:42/196 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SLQMSEMSKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVT-----RLEKADIL 62
            |::..:...||   |:...::|:|||.|||:|:.:||||:       .||:.     .||||.:|
Human    35 SMKRDDTKDTY---KLPHRLIEKKRRDRINECIAQLKDLL-------PEHLKLTTLGHLEKAVVL 89

  Fly    63 ELTVTHLQKMK--QQRQHKR----ASGDESL-----TPAEGFRSGYIHAVNEVSRSLSQLPGMNV 116
            |||:.||:.:.  .::||::    .:|:.||     :..:.|.||:.....||.:.||:....  
Human    90 ELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESW-- 152

  Fly   117 SLGTQLMTHLGQRLNQIQPAEKEVLPVTAPLSVHIANRDAYSVPISPISSYAGSPNSNTSSTSHS 181
               |.......|.:|.:.....:.||....|:..:           |:|...|:|::..|:.:..
Human   153 ---TPREPRCVQLINHLHAVATQFLPTPQLLTQQV-----------PLSKGTGAPSAAGSAAAPC 203

  Fly   182 L 182
            |
Human   204 L 204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)mgamma-HLHNP_524504.2 HLH 15..77 CDD:238036 25/68 (37%)
ORANGE 91..135 CDD:128787 10/43 (23%)
BHLHE41NP_110389.1 bHLH-O_DEC2 31..122 CDD:381593 33/96 (34%)
Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269|PubMed:19786558 67..71 3/3 (100%)
ORANGE 129..175 CDD:128787 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140895
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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