DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and bhlhe40

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	XP_004914192.2	Gene:	bhlhe40 / 779502	XenbaseID:	XB-GENE-486416	Length:	385	Species:	Xenopus tropicalis

Alignment Length:	214	Identity:	60/214 - (28%)
Similarity:	94/214 - (43%)	Gaps:	58/214 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLQMSEMSKTYQYRKVMK--------------PMLERKRRARINKCLDELKDLMVATLESEGE 51
            :|.:..|.|...:::||.:|              .::|:|||.|||:|:.:||||:       .|
Frog    46 LSGMDFSHMYPVFKHRKALKRCEESKQDTYKLPHRLIEKKRRDRINECIAQLKDLL-------PE 103

  Fly    52 HVT-----RLEKADILELTVTHLQKM----KQQRQH--KRASGDES----LTPAEGFRSGYIHAV 101
            |:.     .||||.:||||:.|::.:    :||:|.  ...||..|    ::..|.|.||:....
Frog   104 HLKLTTLGHLEKAVVLELTLKHVRSLSSLIEQQQQQILTLQSGSPSEENRISAEEMFHSGFQLCA 168

  Fly   102 NEVSRSLSQLPGMNVSLG---TQLMTHLGQRLNQIQPA------EKEVLPVTAPLSVHIANRDAY 157
            .|..|.|.         |   .:|:.||.:..:::.||      ||.|..|.|...|.:..|.|
Frog   169 EEALRFLQ---------GGERKELVAHLHRVASKLGPASFPKVTEKPVPKVQATNCVPVICRAA- 223

  Fly   158 SVPISPISSYAGSPNSNTS 176
              |: |....:|:.....|
Frog   224 --PL-PSGEQSGTDTDTDS 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	28/84 (33%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	11/46 (24%)
bhlhe40	XP_004914192.2	bHLH_SF	61..151	CDD:412148	32/96 (33%)
bhlhe40	XP_004914192.2	Hairy_orange	160..192	CDD:400076	10/40 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010